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MYOCARDITIS
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Heymans, Stephane


Publications

Impact Factor

Cites


ReferenceImpact FactorCitesQuartile
Heymans S, Cooper LT. Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms. Nat Rev Cardiol. 2022 Feb;19(2):75-77. doi: 10.1038/s41569-021-00662-w. PubMed PMID: 34887571; PubMed Central PMCID: PMC8656440.
49.421
Tschope C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hubner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S. Myocarditis and inflammatory cardiomyopathy: current evidence and future directions. Nat Rev Cardiol. 2021 Mar;18(3):169-193. doi: 10.1038/s41569-020-00435-x. Epub 2020 Oct 12. PubMed PMID: 33046850; PubMed Central PMCID: PMC7548534.
49.421
Lota AS, Hazebroek MR, Theotokis P, Wassall R, Salmi S, Halliday BP, Tayal U, Verdonschot J, Meena D, Owen R, de Marvao A, Iacob A, Yazdani M, Hammersley DJ, Jones RE, Wage R, Buchan R, Vivian F, Hafouda Y, Noseda M, Gregson J, Mittal T, Wong J, Robertus JL, Baksi AJ, Vassiliou V, Tzoulaki I, Pantazis A, Cleland JGF, Barton PJR, Cook SA, Pennell DJ, Garcia-Pavia P, Cooper LT Jr, Heymans S, Ware JS, Prasad SK. Genetic Architecture of Acute Myocarditis and the Overlap With Inherited Cardiomyopathy. Circulation. 2022 Oct 11;146(15):1123-1134. doi: 10.1161/CIRCULATIONAHA.121.058457. Epub 2022 Sep 26. PubMed PMID: 36154167; PubMed Central PMCID: PMC9555763.
39.918
Heymans S, Pauschinger M, De Palma A, Kallwellis-Opara A, Rutschow S, Swinnen M, Vanhoutte D, Gao F, Torpai R, Baker AH, Padalko E, Neyts J, Schultheiss HP, Van de Werf F, Carmeliet P, Pinto YM. Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis. Circulation. 2006 Aug 8;114(6):565-73. doi: 10.1161/CIRCULATIONAHA.105.591032. Epub 2006 Jul 31. PubMed PMID: 16880329.
39.918
Rother M, Krohn S, Kania G, Vanhoutte D, Eisenreich A, Wang X, Westermann D, Savvatis K, Dannemann N, Skurk C, Hilfiker-Kleiner D, Cathomen T, Fechner H, Rauch U, Schultheiss HP, Heymans S, Eriksson U, Scheibenbogen C, Poller W. Matricellular signaling molecule CCN1 attenuates experimental autoimmune myocarditis by acting as a novel immune cell migration modulator. Circulation. 2010 Dec 21;122(25):2688-98. doi: 10.1161/CIRCULATIONAHA.110.945261. Epub 2010 Dec 6. PubMed PMID: 21135363.
39.918
Fanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Longhi MP, Vyas VS, Dyer C, Pontarini E, Asimaki A, Bueno-Beti C, De Gaspari M, Rizzo S, Basso C, Bombardieri M, Coe D, Wang G, Harding D, Gallagher I, Solito E, Elliott P, Heymans S, Sikking M, Savvatis K, Mohiddin SA, Marelli-Berg FM. Circulating c-Met-Expressing Memory T Cells Define Cardiac Autoimmunity. Circulation. 2022 Dec 20;146(25):1930-1945. doi: 10.1161/CIRCULATIONAHA.121.055610. Epub 2022 Nov 23. PubMed PMID: 36417924; PubMed Central PMCID: PMC9770129.
39.918
Heymans S, Corsten MF, Verhesen W, Carai P, van Leeuwen RE, Custers K, Peters T, Hazebroek M, Stoger L, Wijnands E, Janssen BJ, Creemers EE, Pinto YM, Grimm D, Schurmann N, Vigorito E, Thum T, Stassen F, Yin X, Mayr M, de Windt LJ, Lutgens E, Wouters K, de Winther MP, Zacchigna S, Giacca M, van Bilsen M, Papageorgiou AP, Schroen B. Macrophage microRNA-155 promotes cardiac hypertrophy and failure. Circulation. 2013 Sep 24;128(13):1420-32. doi: 10.1161/CIRCULATIONAHA.112.001357. Epub 2013 Aug 16. Erratum In: Circulation. 2020 May 12;141(19):e808. PubMed PMID: 23956210.
39.918
Pinto YM, Heymans S. Letter by Pinto and Heymans regarding article, "Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice". Circulation. 2008 Nov 11;118(20):e697. doi: 10.1161/CIRCULATIONAHA.108.787697. No abstract available. PubMed PMID: 19001029.
39.918
Dennert R, Crijns HJ, Heymans S. Acute viral myocarditis. Eur Heart J. 2008 Sep;29(17):2073-82. doi: 10.1093/eurheartj/ehn296. Epub 2008 Jul 9. PubMed PMID: 18617482; PubMed Central PMCID: PMC2519249.
35.855
Heymans S. Myocarditis and heart failure: need for better diagnostic, predictive, and therapeutic tools. Eur Heart J. 2007 Jun;28(11):1279-80. doi: 10.1093/eurheartj/ehm111. Epub 2007 May 9. No abstract available. PubMed PMID: 17493944.
35.855
Caforio AL, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, Fu M, Helio T, Heymans S, Jahns R, Klingel K, Linhart A, Maisch B, McKenna W, Mogensen J, Pinto YM, Ristic A, Schultheiss HP, Seggewiss H, Tavazzi L, Thiene G, Yilmaz A, Charron P, Elliott PM; European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2013 Sep;34(33):2636-48, 2648a-2648d. doi: 10.1093/eurheartj/eht210. Epub 2013 Jul 3. PubMed PMID: 23824828.
35.855
Loebel M, Holzhauser L, Hartwig JA, Shukla PC, Savvatis K, Jenke A, Gast M, Escher F, Becker SC, Bauer S, Stroux A, Beling A, Kespohl M, Pinkert S, Fechner H, Kuehl U, Lassner D, Poller W, Schultheiss HP, Zeller T, Blankenberg S, Papageorgiou AP, Heymans S, Landmesser U, Scheibenbogen C, Skurk C. The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance in myocarditis. Eur Heart J. 2018 Mar 7;39(10):876-887. doi: 10.1093/eurheartj/ehx624. PubMed PMID: 29136142.
35.855
Corsten MF, Heggermont W, Papageorgiou AP, Deckx S, Tijsma A, Verhesen W, van Leeuwen R, Carai P, Thibaut HJ, Custers K, Summer G, Hazebroek M, Verheyen F, Neyts J, Schroen B, Heymans S. The microRNA-221/-222 cluster balances the antiviral and inflammatory response in viral myocarditis. Eur Heart J. 2015 Nov 7;36(42):2909-19. doi: 10.1093/eurheartj/ehv321. Epub 2015 Jul 22. PubMed PMID: 26206211.
35.855
Heymans S, Dawson D, Fuster V, Metra M, Tocchetti CG. Myocarditis Following SARS-CoV2 mRNA Vaccination Against COVID-19: Facts and Open Questions. J Am Coll Cardiol. 2022 Oct 4;80(14):1363-1365. doi: 10.1016/j.jacc.2022.08.003. No abstract available. PubMed PMID: 36175054; PubMed Central PMCID: PMC9512040.
27.203
Heymans S, Eriksson U, Lehtonen J, Cooper LT Jr. The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy. J Am Coll Cardiol. 2016 Nov 29;68(21):2348-2364. doi: 10.1016/j.jacc.2016.09.937. PubMed PMID: 27884253.
27.203
Corsten MF, Papageorgiou A, Verhesen W, Carai P, Lindow M, Obad S, Summer G, Coort SL, Hazebroek M, van Leeuwen R, Gijbels MJ, Wijnands E, Biessen EA, De Winther MP, Stassen FR, Carmeliet P, Kauppinen S, Schroen B, Heymans S. MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis. Circ Res. 2012 Aug 3;111(4):415-25. doi: 10.1161/CIRCRESAHA.112.267443. Epub 2012 Jun 19. PubMed PMID: 22715471.
23.213
Gentile P, Merlo M, Peretto G, Ammirati E, Sala S, Della Bella P, Aquaro GD, Imazio M, Potena L, Campodonico J, Foa A, Raafs A, Hazebroek M, Brambatti M, Cercek AC, Nucifora G, Shrivastava S, Huang F, Schmidt M, Muser D, Van de Heyning CM, Van Craenenbroeck E, Aoki T, Sugimura K, Shimokawa H, Cannata A, Artico J, Porcari A, Colopi M, Perkan A, Bussani R, Barbati G, Garascia A, Cipriani M, Agostoni P, Pereira N, Heymans S, Adler ED, Camici PG, Frigerio M, Sinagra G. Post-discharge arrhythmic risk stratification of patients with acute myocarditis and life-threatening ventricular tachyarrhythmias. Eur J Heart Fail. 2021 Dec;23(12):2045-2054. doi: 10.1002/ejhf.2288. Epub 2021 Jul 21. PubMed PMID: 34196079.
17.349
Verdonschot J, Hazebroek M, Merken J, Debing Y, Dennert R, Brunner-La Rocca HP, Heymans S. Relevance of cardiac parvovirus B19 in myocarditis and dilated cardiomyopathy: review of the literature. Eur J Heart Fail. 2016 Dec;18(12):1430-1441. doi: 10.1002/ejhf.665. Epub 2016 Oct 17. PubMed PMID: 27748022.
17.349
de Boer RA, De Keulenaer G, Bauersachs J, Brutsaert D, Cleland JG, Diez J, Du XJ, Ford P, Heinzel FR, Lipson KE, McDonagh T, Lopez-Andres N, Lunde IG, Lyon AR, Pollesello P, Prasad SK, Tocchetti CG, Mayr M, Sluijter JPG, Thum T, Tschope C, Zannad F, Zimmermann WH, Ruschitzka F, Filippatos G, Lindsey ML, Maack C, Heymans S. Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology. Eur J Heart Fail. 2019 Mar;21(3):272-285. doi: 10.1002/ejhf.1406. Epub 2019 Feb 4. PubMed PMID: 30714667; PubMed Central PMCID: PMC6607480.
17.349
Corsten MF, Schroen B, Heymans S. Inflammation in viral myocarditis: friend or foe? Trends Mol Med. 2012 Jul;18(7):426-37. doi: 10.1016/j.molmed.2012.05.005. Epub 2012 Jun 20. PubMed PMID: 22726657.
15.272
Camporeale A, Marino F, Papageorgiou A, Carai P, Fornero S, Fletcher S, Page BD, Gunning P, Forni M, Chiarle R, Morello M, Jensen O, Levi R, Heymans S, Poli V. STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy. EMBO Mol Med. 2013 Apr;5(4):572-90. doi: 10.1002/emmm.201201876. Epub 2013 Mar 5. PubMed PMID: 23460527; PubMed Central PMCID: PMC3628107.
14.26
Papageorgiou AP, Heggermont W, Rienks M, Carai P, Langouche L, Verhesen W, De Boer RA, Heymans S. Liver X receptor activation enhances CVB3 viral replication during myocarditis by stimulating lipogenesis. Cardiovasc Res. 2015 Jul 1;107(1):78-88. doi: 10.1093/cvr/cvv157. Epub 2015 May 21. PubMed PMID: 25998987.
13.081
Papageorgiou AP, Swinnen M, Vanhoutte D, VandenDriessche T, Chuah M, Lindner D, Verhesen W, de Vries B, D'hooge J, Lutgens E, Westermann D, Carmeliet P, Heymans S. Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells. Cardiovasc Res. 2012 Apr 1;94(1):115-24. doi: 10.1093/cvr/cvs077. Epub 2012 Feb 2. PubMed PMID: 22308237.
13.081
Carai P, Florit Gonzalez L, Van Bruggen S, Spalart V, De Giorgio D, Geuens N, Martinod K, Jones EAV, Heymans S. NEUTROPHIL INHIBITION IMPROVES ACUTE INFLAMMATION IN A MURINE MODEL OF VIRAL MYOCARDITIS. Cardiovasc Res. 2022 Apr 15:cvac052. doi: 10.1093/cvr/cvac052. Online ahead of print. PubMed PMID: 35426438.
13.081
Rienks M, Carai P, van Teeffelen J, Eskens B, Verhesen W, Hemmeryckx B, Johnson DM, van Leeuwen R, Jones EA, Heymans S, Papageorgiou AP. SPARC preserves endothelial glycocalyx integrity, and protects against adverse cardiac inflammation and injury during viral myocarditis. Matrix Biol. 2018 Dec;74:21-34. doi: 10.1016/j.matbio.2018.04.015. Epub 2018 May 3. PubMed PMID: 29730504.
10.447
Rienks M, Papageorgiou A, Wouters K, Verhesen W, Leeuwen RV, Carai P, Summer G, Westermann D, Heymans S. A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis. Cell Mol Life Sci. 2017 Apr;74(8):1511-1525. doi: 10.1007/s00018-016-2423-7. Epub 2016 Nov 23. PubMed PMID: 27878326; PubMed Central PMCID: PMC5357299.
9.207
Eurlings C, Heymans S. Diastolic heart failure after acute myocarditis, a new discovery in inflammatory cardiomyopathies? Heart. 2011 May;97(9):685-6. doi: 10.1136/hrt.2010.214916. Epub 2011 Jan 6. No abstract available. PubMed PMID: 21212132.
7.365
Remels AHV, Derks WJA, Cillero-Pastor B, Verhees KJP, Kelders MC, Heggermont W, Carai P, Summer G, Ellis SR, de Theije CC, Heeren RMA, Heymans S, Papageorgiou AP, van Bilsen M. NF-kappaB-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis. Biochim Biophys Acta Mol Basis Dis. 2018 Aug;1864(8):2579-2589. doi: 10.1016/j.bbadis.2018.04.022. Epub 2018 May 3. PubMed PMID: 29730342.
6.633
Emmens RW, Woudstra L, Papageorgiou A, Carai P, Smit S, Seven-Deniz S, Rozendaal L, Paulus WJ, Wouters D, Zeerleder S, Murk JL, van Ham MS, Heymans S, van Rossum AC, Niessen HW, Krijnen PA. Lymphocytes infiltrate the quadriceps muscle in lymphocytic myocarditis patients: a potential new diagnostic tool. Can J Cardiol. 2014 Dec;30(12):1547-54. doi: 10.1016/j.cjca.2014.07.018. Epub 2014 Jul 22. PubMed PMID: 25442457.
6.614
Favere K, Bosman M, Klingel K, Heymans S, Van Linthout S, Delputte PL, De Sutter J, Heidbuchel H, Guns PJ. Toll-Like Receptors: Are They Taking a Toll on the Heart in Viral Myocarditis? Viruses. 2021 May 27;13(6):1003. doi: 10.3390/v13061003. PubMed PMID: 34072044; PubMed Central PMCID: PMC8227433.
5.818
Carai P, Papageorgiou AP, Van Linthout S, Deckx S, Velthuis S, Lutgens E, Wijnands E, Tschope C, Schmuttermaier C, Kzhyshkowska J, Jones EAV, Heymans S. Stabilin-1 mediates beneficial monocyte recruitment and tolerogenic macrophage programming during CVB3-induced viral myocarditis. J Mol Cell Cardiol. 2022 Apr;165:31-39. doi: 10.1016/j.yjmcc.2021.12.009. Epub 2021 Dec 28. PubMed PMID: 34968453.
5.763
Porcari A, Merlo M, Baggio C, Gagno G, Cittar M, Barbati G, Paldino A, Castrichini M, Vitrella G, Pagnan L, Cannata A, Andreis A, Cecere A, Cipriani A, Raafs A, Bromage DI, Rosmini S, Scott P, Sado D, Di Bella G, Nucifora G, Marra MP, Heymans S, Imazio M, Sinagra G. Global longitudinal strain by CMR improves prognostic stratification in acute myocarditis presenting with normal LVEF. Eur J Clin Invest. 2022 Oct;52(10):e13815. doi: 10.1111/eci.13815. Epub 2022 May 29. PubMed PMID: 35598175.
5.722
Carai P, Ruozi G, Paye A, Debing Y, Bortolotti F, Lecomte J, Zentilin L, Jones EAV, Giacca M, Heymans S. AAV9-mediated functional screening for cardioprotective cytokines in Coxsackievirus-B3-induced myocarditis. Sci Rep. 2022 May 4;12(1):7304. doi: 10.1038/s41598-022-11131-w. PubMed PMID: 35508525; PubMed Central PMCID: PMC9067557.
4.996
Smilde BJ, Woudstra L, Fong Hing G, Wouters D, Zeerleder S, Murk JL, van Ham M, Heymans S, Juffermans LJ, van Rossum AC, Niessen HW, Krijnen PA, Emmens RW. Reply to the letter to the editor "Is colchicine really harmful in viral myocarditis?". Int J Cardiol. 2017 Feb 15;229:43. doi: 10.1016/j.ijcard.2016.11.292. Epub 2016 Nov 26. No abstract available. PubMed PMID: 27916345.
4.039
Hazebroek MR, van Paassen P, Weerwind PW, Cooper LT Jr, Uriel N, Caliskan K, de Vries B, Maessen JG, Autschbach R, Heymans S, Donker DW. A passionate endurance cyclist ultimately survives sudden death in right ventricular giant cell myocarditis. Int J Cardiol. 2014 Jan 1;170(3):e74-5. doi: 10.1016/j.ijcard.2013.11.028. Epub 2013 Nov 16. No abstract available. PubMed PMID: 24290425.
4.039
Woudstra L, Biesbroek PS, Emmens RW, Heymans S, Juffermans LJ, van Rossum AC, Niessen HW, Krijnen PA. Lymphocytic myocarditis occurs with myocardial infarction and coincides with increased inflammation, hemorrhage and instability in coronary artery atherosclerotic plaques. Int J Cardiol. 2017 Apr 1;232:53-62. doi: 10.1016/j.ijcard.2017.01.052. Epub 2017 Jan 7. PubMed PMID: 28087177.
4.039
Smilde BJ, Woudstra L, Fong Hing G, Wouters D, Zeerleder S, Murk JL, van Ham M, Heymans S, Juffermans LJ, van Rossum AC, Niessen HW, Krijnen PA, Emmens RW. Colchicine aggravates coxsackievirus B3 infection in mice. Int J Cardiol. 2016 Aug 1;216:58-65. doi: 10.1016/j.ijcard.2016.04.144. Epub 2016 Apr 19. PubMed PMID: 27140338.
4.039
Begieneman MP, Emmens RW, Rijvers L, Kubat B, Paulus WJ, Vonk AB, Rozendaal L, Biesbroek PS, Wouters D, Zeerleder S, van Ham M, Heymans S, van Rossum AC, Niessen HW, Krijnen PA. Ventricular myocarditis coincides with atrial myocarditis in patients. Cardiovasc Pathol. 2016 Mar-Apr;25(2):141-8. doi: 10.1016/j.carpath.2015.12.001. Epub 2015 Dec 4. PubMed PMID: 26764148.
3.975
Deckx S, Johnson DM, Rienks M, Carai P, Van Deel E, Van der Velden J, Sipido KR, Heymans S, Papageorgiou AP. Extracellular SPARC increases cardiomyocyte contraction during health and disease. PLoS One. 2019 Apr 1;14(4):e0209534. doi: 10.1371/journal.pone.0209534. eCollection 2019. PubMed PMID: 30933983; PubMed Central PMCID: PMC6443176.
3.752
Timmermans P, Barradas-Pires A, Ali O, Henkens M, Heymans S, Negishi K. Prednisone and azathioprine in patients with inflammatory cardiomyopathy: systematic review and meta-analysis. ESC Heart Fail. 2020 Oct;7(5):2278-2296. doi: 10.1002/ehf2.12762. Epub 2020 Jul 27. PubMed PMID: 33121219; PubMed Central PMCID: PMC7524236.
3.612
Woudstra L, Biesbroek PS, Emmens RW, Heymans S, Juffermans LJ, van der Wal AC, van Rossum AC, Niessen HWM, Krijnen PAJ. CD45 is a more sensitive marker than CD3 to diagnose lymphocytic myocarditis in the endomyocardium. Hum Pathol. 2017 Apr;62:83-90. doi: 10.1016/j.humpath.2016.11.006. Epub 2016 Dec 23. PubMed PMID: 28025077.
3.526
Papageorgiou AP, Heymans S. Interactions between the extracellular matrix and inflammation during viral myocarditis. Immunobiology. 2012 May;217(5):503-10. doi: 10.1016/j.imbio.2011.07.011. Epub 2011 Jul 18. PubMed PMID: 21907443.
3.152
Dennert R, Velthuis S, Westermann D, Donker D, Schalla S, van Suylen RJ, Heymans S. Parvovirus-B19-associated fulminant myocarditis successfully treated with immunosuppressive and antiviral therapy. Antivir Ther. 2010;15(4):681-5. doi: 10.3851/IMP1563. PubMed PMID: 20587861.
1.679
Corsten MF, Dennert R, Jochems S, Kuznetsova T, Devaux Y, Hofstra L, Wagner DR, Staessen JA, Heymans S, Schroen B. Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease. Circ Cardiovasc Genet. 2010 Dec;3(6):499-506. doi: 10.1161/CIRCGENETICS.110.957415. Epub 2010 Oct 4. PubMed PMID: 20921333.
Hazebroek M, Dennert R, Heymans S. Virus infection of the heart--unmet therapeutic needs. Antivir Chem Chemother. 2012 Aug 21;22(6):249-53. doi: 10.3851/IMP2047. PubMed PMID: 22293868.

Data Sources

PubMed
NCBI
SemanticScholar
Web of Science
Human Phenotype ontology
KEGG
IMIB-Arrixaca

Address

Biomedical Informatics & Bioinformatics Platform
Institute for Bio-health Research of Murcia (IMIB-Arrixaca)
Carretera Buenavista s/n, 30120
El Palmar, Murcia, Spain

E-mail

Phones

+34 968885229
+34 968885239
+34 968885249

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